Methods for counteracting the deleterious effects of sodium chloride

ABSTRACT

A substantially tasteless, non-toxic composition comprising sodium chloride and a magnesium compound containing bivalent negative sulfur and method of using the compositions to control the deleterious effects of large amounts of sodium chloride on the human body.

FIELD OF THE INVENTION

This invention relates to new and useful improvements in a compositionand process for reducing the deleterious effects of ingested sodiumchloride and, more particularly, relates to a composition or mixtureincluding sodium chloride and a magnesium compound containing bivalentnegative sulfur.

BACKGROUND OF THE INVENTION

It has become apparent in recent years that the ingestion of sodiumchloride, especially at the higher levels to which humans have becomeaccustomed, has deleterious effects, mainly related to thecardiovascular system, e.g., high blood pressure and arteriosclerosis,but also encourages growth of tumors. Efforts to restrict the ingestionof salt by eating low or unsalted food or substituting condiments hasnot been very successful.

DESCRIPTION OF THE INVENTION

A study of the biological activity of compounds has shown that theyinclude either destructive-catabolic or constructive-anabolic actions inthe human body. The manifestations of an abnormal condition, assymptoms, signs, pathology analyses and response to therapy are relatedto this dualism. Hypertension, arteriosclerosis and the growth of tumorsare recognized as typical constructive anabolic manifestations. On theother hand, I have shown that the action of compounds upon the body haseither an anabolic or a catabolic action. Thus, compounds can beclassified as anabolic or catabolic by a series of tests.

By tests, such as of the effect on the second day wound crust pH, or onthe curve of the healing of a wound, or on the bloor eosinophileleukocytes and potassium, or on the urine pH, surface tension, specificgravity and chloride excretion, compounds can be established as eitheranabolic constructive or catabolic destructive.

Through the study from this point of view of the biological actions ofthe elements, I have shown that the members of the different series(vertical grouping) of the periodic table have either anabolic orcatabolic actions. The IA series, to which the sodium belongs, hasanabolic actions. The same for the IIIA, VA and VIIA, to which thechloride element belongs. Sodium chloride consequently produces highanabolic effects. Oppositely, I have shown that the series IIA, IVA andVIA have antagonistic catabolic effects.

I have further found that the elements of the same period (horizontalgrouping) act at the same level of the body organization, such assubnuclear, nuclear, cellular, metazoic or systemic, and that the sodiumand the chloride act at the same metazoic level (tissues and organs).The biological effect of sodium chloride is thus a strong anabolicaction at the metazoic level. This explains the noxious action upon theblood pressure and arteries, leading to the anabolic-constructivearteriosclerosis.

Following the same systematization of the elements acting at the samemetazoic level as the sodium and chloride but having an oppositecatabolic action, it appeared that the use of one or more of thecatabolic metazoic elements would produce the opposite action of thisbiological effect of the sodium chloride.

This was shown to be true experimentally. Magnesium was seen to beopposite biologically to sodium, while the sulfur biologically oppositechlorine. In the case of sulfur, it was found that the bivalent negativewas more active than the tetra- and hexa-valent positive.

Based on these primary considerations, compounds having magnesium andsulfur were used, in order to show this antagonism as set forth in thefollowing experiments.

The bilateral adrenalectomy in young rats, of below 150 g, was seen tohave almost 100% mortality. The administration of 1% solutions of sodiumchloride as drinking water was seen to protect the adrenalectomizedanimals and, if administered for a sufficient length of time, to preventthe death. The administration together with the sodium chloride ofmagnesium sulfate, the last in subcutaneous repeated injections of 0.5ml of a 10% solution for 100 g of animal or orally as 1% in drinkingwater, was seen to be antagonistic to the action of the sodium chloride.In the adrenalectomized animals treated with sodium chloride andmagnesium sulfate the mortality was over 80% instead of almost zero forthe adrenalectomized animals receiving only the sodium chloride. Thesame for the older animals, to which the administration of magnesiumsulfate (1% in drinking water) was seen to increase the mortality from20% in controls to 75% in the animals receiving the magnesium sulfate.The use of the magnesium thiosulfate was still more effective than themagnesium sulfate.

The relationship between sodium chloride, magnesium sulfates andarteriosclerosis was seen in the following experiments.

New Zealand rabbits were given 2 grams of cholesterol a day, orally,together with their food. Sacrificed after one month, they showedatheromatous lesions of the aorta. The animals sacrificed after only twoweeks of receiving the cholesterol showed only few minimal lesions ornone at all. The addition of sodium chloride (3% to the drinking water)to the animals receiving 2 g of cholesterol daily was seen to inducemanifest aorta lesions and this after only two weeks of treatment withcholesterol.

The administration of magnesium thiosulfate at 3%, together with the 3%sodium chloride in the drinking water, was seen to prevent theappearance of the aorta lesions, not only after two weeks as in thecontrols with NaCl alone, but even after one month.

As noted above, antagonism exists between magnesium and sodium whichcounteracts the biological action of sodium and that the same antagonismexists between the chlorine and sulfur, especially in the bivalentnegative state.

It is thus possible to overcome the adverse effects of sodium chlorideby adding various magnesium compounds, such as magnesium oxide ormagnesium acetylsalicylate and the sulfur compounds separately. Varioussulfur compounds or even colloidal sulfur can be used for this purpose.The ingestation of colloidal sulfur has been found to produce sulfidesin the intestines of animals. The bond of magnesium to catabolic sulfurenhances this antisodium action. It has been found that the best resultsare obtained by utilizing a magnesium compound containing bivalentnegative sulfur and especially magnesium thiosulfate.

The composition is prepared by merely mixing sodium chloride withmagnesium thiosulfate, preferably previously heated around 170° C. inorder to eliminate or reduce its hydrated water. The crystals ofmagnesium thiosulfate are preferably ground to a fine powder beforemixing with sodium chloride. The sodium chloride crystals can also beground to a fine powder if desired. In this manner the taste ofmagnesium thiosulfate in the composition is substantially reduced. Theamount of magnesium thiosulfate should be at least about 1% by weight ofthe total composition in order to subsequently antagonize the adverseeffects of sodium chloride. Amounts as high as 10% by weight ofmagnesium thiosulfate can be employed without substantially affectingthe taste of the sodium chloride. Amounts as high as 25% by weight couldbe used where taste is not a factor.

Other catabolic agents, of a lower organizational level of the cells,such as Ca, Sc, V, Mn, Co, Cu, Ge and Se may be added together with themagnesium and sulfur.

Other antianabolic agents, such as vitamins A, D, B₆ and B₁₂, fattyacids, aldehydes, and the special group of agents having a twinformation (2 atoms with the same electrical charge bound together) canalso be added to the magnesium-sulfur agents if desired.

I claim:
 1. A method for counteracting the adverse effects of sodiumchloride on the human body which comprises administering to said body acomposition containing sodium chloride and a magnesium compoundcontaining bivalent negative sulfur where said magnesium compound ispresent in an amount effective to counteract the adverse effects of saidsodium chloride.
 2. The method of claim 1 in which the amount ofmagnesium compound is between about 1 and 10% by weight of the sodiumchloride.
 3. The method of claim 1 where the magnesium compound ismagnesium thiosulfate.